产品名称
NVL Rabbit Polyclonal Antibody
别名
NVL; Nuclear valosin-containing protein-like; NVLp; Nuclear VCP-like protein
蛋白名称
Nuclear valosin-containing protein-like
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4931
Human Swissprot No.
O15381
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O15381/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=67459
Mouse Swissprot No.
Q9DBY8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9DBY8
免疫原
Synthesized peptide derived from NVL . at AA range: 320-400
特异性
NVL Polyclonal Antibody detects endogenous levels of NVL protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynthesis (PMID: 15469983, 16782053), while the minor isoform has been localized to the nucleoplasmin. [provided by RefSeq, Aug 2011],
组织表达
Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina.
细胞定位
[Isoform 2]: Nucleus, nucleoplasm .; [Isoform 1]: Nucleus, nucleolus . Nucleus, nucleoplasm . Expressed predominantly in the nucleolus. Associates with pre-ribosomal particles in the nucleus. .
功能
PTM:Phosphorylated.,similarity:Belongs to the AAA ATPase family.,tissue specificity:Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
