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NPAS2 Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PT5045
产品名称
NPAS2 Rabbit Polyclonal Antibody
别名
NPAS2; BHLHE9; MOP4; PASD4; Neuronal PAS domain-containing protein 2; Neuronal PAS2; Basic-helix-loop-helix-PAS protein MOP4; Class E basic helix-loop-helix protein 9; bHLHe9; Member of PAS protein 4; PAS domain-containing protein 4
类别
常规抗体
基因名称
NPAS2
蛋白名称
Neuronal PAS domain-containing protein 2
推荐应用
WB
反应种属
Human,Rat
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
4862
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4862
Human Swissprot No.
Q99743
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q99743/entry
Mouse Swissprot No.
P97460
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P97460
免疫原
Synthesized peptide derived from NPAS2 . at AA range: 340-420
特异性
NPAS2 Polyclonal Antibody detects endogenous levels of NPAS2 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
预测分子量
91kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. [provided by RefSeq, Jul 2008],
组织表达
Human lung,Lung,
细胞定位
Nucleus .
信号通路
Circadian rhythm;
功能
function:BMAL1-NPAS2 heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins.,polymorphism:Variants in NPAS2 show a susceptibility to seasonal affective disorder (SAD) [MIM:608516]. SAD is a depressive condition resulting from seasonal changes, and with diurnal preference.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 2 PAS (PER-ARNT-SIM) domains.,subunit:Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerization with CLOCK or NPAS2 is required for E-box-dependent transactivation.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Western Blot analysis of extracts from rat stomach, 293 cells, using NPAS2 Polyclonal Antibody.. Secondary antibody was diluted at 1:20000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).

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