产品名称
LAT4 Rabbit Polyclonal Antibody
别名
Large neutral amino acids transporter small subunit 4 (L-type amino acid transporter 4) (Solute carrier family 43 member 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.167% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/124935
Human Swissprot No.
Q8N370
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8N370/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/215113
Mouse Swissprot No.
Q8CGA3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CGA3
免疫原
Synthesized peptide derived from human LAT4 AA range: 122-172
特异性
This antibody detects endogenous levels of LAT4 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the L-amino acid transporter-3 or SLC43 family of transporters. The encoded protein mediates sodium-, chloride-, and pH-independent transport of L-isomers of neutral amino acids, including leucine, phenylalanine, valine and methionine. This protein may contribute to the transfer of amino acids across the placental membrane to the fetus. [provided by RefSeq, Mar 2016],
组织表达
Detected in several tissues with higher expression in placenta, kidney and peripheral blood leukocytes. In the kidney, is detected in epithelial cells of the distal tubule and collecting duct. In the intestine, is expressed mainly in crypt cells of the intestinal microvilli and epithelial cells in the base of the villus.
细胞定位
Membrane ; Multi-pass membrane protein .
功能
function:Sodium-, chloride, pH-independent high affinity transport of large neutral amino acids.,PTM:Glycosylated.,similarity:Belongs to the SLC43A transporter (TC 2.A.1.44) family.,tissue specificity:Detected in several tissues with, higher expression in placenta, kidney and peripheral blood leukocytes. In the kidney is detected in epithelial cells of the distal tubule and collecting duct. In the intestin is expressed mainly in crypt cells of the intestinal microvilli ans epithelial cells in the base of the villus.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
