产品名称
MEX3B Rabbit Polyclonal Antibody
别名
RNA-binding protein MEX3B (RING finger and KH domain-containing protein 3) (RING finger protein 195)
基因名称
MEX3B KIAA2009 RKHD3 RNF195
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.168% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/84206
Human Swissprot No.
Q6ZN04
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6ZN04/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/0
Mouse Swissprot No.
Q69Z36
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q69Z36
免疫原
Synthesized peptide derived from human MEX3B AA range: 434-484
特异性
This antibody detects endogenous levels of MEX3B at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an RNA-binding phosphoprotein that is part of the MEX3 (muscle excess 3) family of translational regulators. The encoded protein contains N-terminal nuclear export and nuclear localization signals and is exported from the cytoplasm to the nucleus. The protein binds to RNA via two KH domains and also colocalizes with MEX3A, Dcp1A decapping factor and Argonaute proteins within P (processing) bodies. [provided by RefSeq, Oct 2012],
组织表达
Highest levels found in fetal brain and testis. Detected in the adult intestinal epithelium, specifically in goblet cell at protein level.
细胞定位
Nucleus . Cytoplasm . Cytoplasm, P-body . Cytoplasmic granule . Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. Localization to P-bodies is dependent on 14-3-3.
功能
domain:Binds RNA through its KH domains.,function:RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms.,PTM:Phosphorylated.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 2 KH domains.,subcellular location:Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway.,tissue specificity:Highest levels found in fetal brain and testis. Detected in the adult intestinal epithelium, specifically in goblet cell at protein level.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
