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GDI-1 Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PT5034
产品名称
GDI-1 Rabbit Polyclonal Antibody
别名
GDI1; GDIL; OPHN2; RABGDIA; XAP4; Rab GDP dissociation inhibitor alpha; Rab GDI alpha; Guanosine diphosphate dissociation inhibitor 1; GDI-1; Oligophrenin-2; Protein XAP-4
类别
常规抗体
基因名称
GDI1
蛋白名称
Rab GDP dissociation inhibitor alpha
推荐应用
WB
反应种属
Human,Mouse,Rat
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
2664
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2664
Human Swissprot No.
P31150
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P31150/entry
Mouse Gene ID
14567
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14567
Mouse Swissprot No.
P50396
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P50396
Rat Gene ID
25183
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25183
Rat Swissprot No.
P50398
Rat Swissprot Link
http://www.uniprot.org/uniprot/P50398
免疫原
The antiserum was produced against synthesized peptide derived from human GDI-1. AA range:394-443
特异性
GDI-1 Polyclonal Antibody detects endogenous levels of GDI-1 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
预测分子量
50kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific mental retardation. [provided by RefSeq, Jul 2008],
组织表达
Brain; predominant in neural and sensory tissues.
细胞定位
Cytoplasm . Golgi apparatus, trans-Golgi network .
功能
disease:Defects in GDI1 are the cause of mental retardation X-linked type 41 (MRX41) [MIM:300104]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.,disease:Defects in GDI1 are the cause of mental retardation X-linked type 48 (MRX48) [MIM:300104]; also known as MRX3.,function:Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.,similarity:Belongs to the Rab GDI family.,tissue specificity:Brain; predominant in neural and sensory tissues.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Western blot analysis of lysates from brain tissue, using GDI-1 antibody.

Western Blot analysis of extracts from K562 cells, using GDI-1 Polyclonal Antibody.. Secondary antibody was diluted at 1:20000

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