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ENaC γ Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PT5032
产品名称
ENaC γ Rabbit Polyclonal Antibody
别名
SCNN1G; Amiloride-sensitive sodium channel subunit gamma; Epithelial Na(+) channel subunit gamma; ENaCG; Gamma-ENaC; Gamma-NaCH; Nonvoltage-gated sodium channel 1 subunit gamma; SCNEG
类别
常规抗体
基因名称
SCNN1G
蛋白名称
Amiloride-sensitive sodium channel subunit gamma
推荐应用
WB
反应种属
Human,Mouse,Rat
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
6340
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6340
Human Swissprot No.
P51170
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P51170/entry
Mouse Gene ID
20278
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20278
Mouse Swissprot No.
Q9WU39
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9WU39
Rat Gene ID
24768
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24768
Rat Swissprot No.
P37091
Rat Swissprot Link
http://www.uniprot.org/uniprot/P37091
免疫原
The antiserum was produced against synthesized peptide derived from human ENaC gamma. AA range:132-181
特异性
ENaC γ Polyclonal Antibody detects endogenous levels of ENaC γ protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
预测分子量
80kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the gamma subunit, and mutations in this gene have been associated with Liddle syndrome. [provided by RefSeq, Apr 2009],
组织表达
Expressed in kidney (at protein level).
细胞定位
Apical cell membrane ; Multi-pass membrane protein . Apical membrane of epithelial cells. .
信号通路
Taste transduction;Aldosterone-regulated sodium reabsorption;
功能
disease:Defects in SCNN1G are a cause of Liddle syndrome [MIM:177200]. It is an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension associated with hypokalemic alkalosis. The disease is caused by constitutive activation of the renal epithelial sodium channel.,function:Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.,PTM:Phosphorylated on serine and threonine residues.,PTM:Ubiquitinated; this targets individual subunits for endocytosis and proteasome-mediated degradation.,similarity:Belongs to the amiloride-sensitive sodium channel family.,subcellular location:Apical membrane of epithelial cells.,subunit:Heterotetramer of two alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1 and WWP2.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Western blot analysis of lysates from A549 cells, using ENaC γ antibody.

Western Blot analysis of extracts from A549 cells, using ENaC γ Polyclonal Antibody. Antibody was diluted at 1:500. Secondary antibody was diluted at 1:20000

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