产品名称
Elmo1 Rabbit Polyclonal Antibody
别名
ELMO1; KIAA0281; Engulfment and cell motility protein 1; Protein ced-12 homolog
蛋白名称
Engulfment and cell motility protein 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9844
Human Swissprot No.
Q92556
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q92556/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=140580
Mouse Swissprot No.
Q8BPU7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BPU7
免疫原
The antiserum was produced against synthesized peptide derived from human Elmo1. AA range:22-71
特异性
Elmo1 Polyclonal Antibody detects endogenous levels of Elmo1 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013],
组织表达
Widely expressed, with a higher expression in the spleen and placenta.
细胞定位
Cytoplasm. Cell membrane. Translocation to plasma membrane seems to be mediated by DOCK1 and CRK.
功能
function:Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.,PTM:Phosphorylated by HCK.,similarity:Contains 1 ELMO domain.,similarity:Contains 1 PH domain.,subcellular location:Translocation to plasma membrane seems to be mediated by DOCK1 and CRK.,subunit:Interacts with BAI1 (By similarity). Interacts directly with the SH3-domain of DOCK1 via its SH3-binding site. Part of a complex with DOCK1 and RAC1. Part of a complex with DOCK1 and CRK isoform CRK-II. Interacts with PLEKHG6.,tissue specificity:Widely expressed, with a higher expression in the spleen and placenta.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
