产品名称
MMP21 Rabbit Polyclonal Antibody
别名
Matrix metalloproteinase-21 (MMP-21) (EC 3.4.24.-)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.169% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/118856
Human Swissprot No.
Q8N119
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8N119/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/214766
Mouse Swissprot No.
Q8K3F2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K3F2
免疫原
Synthesized peptide derived from human MMP21 AA range: 425-475
特异性
This antibody detects endogenous levels of MMP21 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, and disease processes, such as asthma and tumor metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival. [provided by RefSeq, May 2013],
组织表达
Identified in fetal brain, kidney and liver. In adult tissues found primarily in ovary, kidney, liver, lung, placenta, brain and peripheral blood leukocytes. Expressed as well in various cancer cell lines.
功能
cofactor:Binds 1 zinc ion per subunit.,cofactor:Calcium.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,function:May have an important and specific function in tumor progression and embryogenesis. Cleaves alpha-1-antitrypsin.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,tissue specificity:Identified in fetal brain, kidney and liver. In adult tissues found primarily in ovary, kidney, liver, lung, placenta, brain and peripheral blood leukocytes. Expressed as well in various cancer cell lines.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
