产品名称
ALDH3A1 Rabbit Polyclonal Antibody
别名
ALDH3A1; ALDH3; Aldehyde dehydrogenase, dimeric NADP-preferring; ALDHIII; Aldehyde dehydrogenase 3; Aldehyde dehydrogenase family 3 member A1
蛋白名称
Aldehyde dehydrogenase dimeric NADP-preferring
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=218
Human Swissprot No.
P30838
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P30838/entry
Mouse Swissprot No.
P47739
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P47739
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25375
Rat Swissprot Link
http://www.uniprot.org/uniprot/P11883
免疫原
The antiserum was produced against synthesized peptide derived from human ALDH3A1. AA range:236-285
特异性
ALDH3A1 Polyclonal Antibody detects endogenous levels of ALDH3A1 protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008],
组织表达
High levels in stomach, esophagus and lung; low level in the liver and kidney.
信号通路
Glycolysis / Gluconeogenesis;Histidine metabolism;Tyrosine metabolism;Phenylalanine metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism;
功能
catalytic activity:An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H.,function:ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes.,similarity:Belongs to the aldehyde dehydrogenase family.,subunit:Homodimer.,tissue specificity:High levels in stomach, esophagus and lung; low level in the liver and kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
