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β-1,4-Gal-T3 Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PT5009
产品名称
β-1,4-Gal-T3 Rabbit Polyclonal Antibody
别名
B4GALT3; Beta-1; 4-galactosyltransferase 3; Beta-1,4-GalTase 3; Beta4Gal-T3; b4Gal-T3; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3
类别
常规抗体
基因名称
B4GALT3
蛋白名称
Beta-1,4-galactosyltransferase 3
推荐应用
WB
反应种属
Human,Mouse,Rat
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
8703
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8703
Human Swissprot No.
O60512
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O60512/entry
Mouse Gene ID
57370
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57370
Mouse Swissprot No.
Q91YY2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91YY2
Rat Gene ID
494342
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=494342
Rat Swissprot No.
Q6P768
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q6P768
免疫原
The antiserum was produced against synthesized peptide derived from human B4GALT3. AA range:271-320
特异性
β-1,4-Gal-T3 Polyclonal Antibody detects endogenous levels of β-1,4-Gal-T3 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
预测分子量
49kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene encodes an enzyme that may be mainly involved in the synthesis of the first N-acetyllactosamine unit of poly-N-acet
组织表达
Found in various tissues. Highest expression in placenta, prostate, testis, ovary, intestine and muscle, and in fetal brain.
细胞定位
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Trans cisternae of Golgi stack.
信号通路
N-Glycan biosynthesis;Keratan sulfate biosynthesis;Glycosphingolipid biosynthesis;
功能
catalytic activity:UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide.,catalytic activity:UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine.,cofactor:Manganese.,function:Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.,online information:Beta-1,4-galactosyltransferase 3,online information:GlycoGene database,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 7 family.,subcellular location:Trans cisternae of Golgi stack.,tissue specificity:Found in various tissues. Highest expression in placenta, prostate, testis, ovary, intestine and muscle, and in fetal brain.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using B4GALT3 Antibody. The picture on the right is blocked with the synthesized peptide.

Western blot analysis of lysates from Jurkat, HeLa, and HepG2 cells, using B4GALT3 Antibody. The lane on the right is blocked with the synthesized peptide.

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