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β-1,4-GalNAc-T Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PT5006
产品名称
β-1,4-GalNAc-T Rabbit Polyclonal Antibody
别名
CSGALNACT1; CHGN; GALNACT1; Chondroitin sulfate N-acetylgalactosaminyltransferase 1; CsGalNAcT-1; Chondroitin beta-1; 4-N-acetylgalactosaminyltransferase 1; Beta4GalNAcT-1
类别
常规抗体
基因名称
CSGALNACT1
蛋白名称
Chondroitin sulfate N-acetylgalactosaminyltransferase 1
推荐应用
WB
反应种属
Human,Mouse,Rat
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
55790
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55790
Human Swissprot No.
Q8TDX6
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8TDX6/entry
Mouse Gene ID
234356
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=234356
Mouse Swissprot No.
Q8BJQ9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BJQ9
免疫原
The antiserum was produced against synthesized peptide derived from human CSGALNACT1. AA range:201-250
特异性
β-1,4-GalNAc-T Polyclonal Antibody detects endogenous levels of β-1,4-GalNAc-T protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
预测分子量
60kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
catalytic activity:UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan = UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosylproteoglycan.,function:Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage.,online information:Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1,online information:GlycoGene database,PTM:N-glycosylated.,similarity:Belongs to the chondroitin N-acetylgalactosaminyltransferase family.,tissue specificity:Ubiquitous, with the highest levels in placenta, thyroid, bladder, prostate and adrenal gland. Detected at low levels in the other tissues examined.,
组织表达
Ubiquitous, with the highest levels in placenta, thyroid, bladder, prostate and adrenal gland. Detected at low levels in the other tissues examined.
细胞定位
Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein .
信号通路
Chondroitin sulfate biosynthesis;
功能
catalytic activity:UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan = UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosylproteoglycan.,function:Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage.,online information:Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1,online information:GlycoGene database,PTM:N-glycosylated.,similarity:Belongs to the chondroitin N-acetylgalactosaminyltransferase family.,tissue specificity:Ubiquitous, with the highest levels in placenta, thyroid, bladder, prostate and adrenal gland. Detected at low levels in the other tissues examined.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using CSGALNACT1 Antibody. The picture on the right is blocked with the synthesized peptide.

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