产品名称
β-1,3-Gal-T1 Rabbit Polyclonal Antibody
别名
B3GALT1; Beta-1; 3-galactosyltransferase 1; Beta-1,3-GalTase 1; Beta3Gal-T1; Beta3GalT1; UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1
蛋白名称
Beta-1,3-galactosyltransferase 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8708
Human Swissprot No.
Q9Y5Z6
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9Y5Z6/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26877
Mouse Swissprot No.
O54904
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O54904
免疫原
The antiserum was produced against synthesized peptide derived from human B3GALT1. AA range:61-110
特异性
β-1,3-Gal-T1 Polyclonal Antibody detects endogenous levels of β-1,3-Gal-T1 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3
组织表达
Detected in brain and colon mucosa and to a lesser extent in colon adenocarcinoma cells.
细胞定位
Golgi apparatus membrane ; Single-pass type II membrane protein .
信号通路
Glycosphingolipid biosynthesis;
功能
cofactor:Manganese.,function:Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues.,online information:Beta-1,3-galactosyltransferase 1,online information:GlycoGene database,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 31 family.,tissue specificity:Detected in brain and colon mucosa and to a lesser extent in colon adenocarcinoma cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
