产品名称
α-protein Kinase 1 Rabbit Polyclonal Antibody
别名
ALPK1; KIAA1527; LAK; Alpha-protein kinase 1; Chromosome 4 kinase; Lymphocyte alpha-protein kinase
蛋白名称
Alpha-protein kinase 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80216
Human Swissprot No.
Q96QP1
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q96QP1/entry
Mouse Swissprot No.
Q9CXB8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9CXB8
免疫原
The antiserum was produced against synthesized peptide derived from human ALPK1. AA range:11-60
特异性
α-protein Kinase 1 Polyclonal Antibody detects endogenous levels of α-protein Kinase 1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an alpha kinase. Mice which were homozygous for disrupted copies of this gene exhibited coordination defects (PMID: 21208416). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],
组织表达
Highly expressed in liver. Expressed in the optic nerve and retinal pigmented epithelium. Lower expression is observed in the macula and extramacular retina (PubMed:30967659).
细胞定位
Cytoplasm, cytosol . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cell projection, cilium . Localized at the base of primary cilia. .
功能
function:Kinases that recognize phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.,similarity:Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.,similarity:Contains 1 alpha-type protein kinase domain.,tissue specificity:Highly expressed in liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
