产品名称
ZP1 Rabbit Polyclonal Antibody
别名
ZP1; Zona pellucida sperm-binding protein 1; Zona pellucida glycoprotein 1; Zp-1
蛋白名称
Zona pellucida sperm-binding protein 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22917
Human Swissprot No.
P60852
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P60852/entry
Mouse Swissprot No.
Q62005
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q62005
免疫原
The antiserum was produced against synthesized peptide derived from human ZP1. AA range:221-270
特异性
ZP1 Polyclonal Antibody detects endogenous levels of ZP1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene ensures the structural integrity of the zona pellucida. Mutations in this gene are a cause of oocyte maturation defect and infertility. [provided by RefSeq, May 2014],
组织表达
Expressed in oocytes (at protein level).
细胞定位
[Processed zona pellucida sperm-binding protein 1]: Zona pellucida .; Cell membrane ; Single-pass type I membrane protein .
功能
domain:The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.,function:The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida.,PTM:O-glycosylated.,PTM:Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.,similarity:Belongs to the ZP domain family. ZPB subfamily.,similarity:Contains 1 P-type (trefoil) domain.,similarity:Contains 1 ZP domain.,subunit:Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers.,tissue specificity:Oocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
