Cn|En

现货抗体产品库

ZnT-8 Rabbit Polyclonal Antibody

产品详情 相关文献 产品问答 相关产品

产品基本信息

产品货号
BD-PT4990
产品名称
ZnT-8 Rabbit Polyclonal Antibody
别名
SLC30A8; ZNT8; Zinc transporter 8; ZnT-8; Solute carrier family 30 member 8
类别
常规抗体
基因名称
SLC30A8
蛋白名称
Zinc transporter 8
推荐应用
WB
反应种属
Human,Rat,Mouse
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
169026
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=169026
Human Swissprot No.
Q8IWU4
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8IWU4/entry
Mouse Swissprot No.
Q8BGG0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BGG0
免疫原
The antiserum was produced against synthesized peptide derived from human SLC30A8. AA range:171-220
特异性
ZnT-8 Polyclonal Antibody detects endogenous levels of ZnT-8 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
预测分子量
41kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010],
组织表达
In the endocrine pancreas, expressed in insulin-producing beta cells. Expressed at relatively high levels in subcutaneous fat tissue from lean persons; much lower levels in visceral fat, whether from lean or obese individuals, and in subcutaneous fat tissue from obese individuals. Expressed in peripheral blood mononuclear cells, including T-cells and B-cells, with great variation among individuals ranging from negative to strongly positive.
细胞定位
Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, secretory vesicle membrane ; Multi-pass membrane protein . Associated with insulin and glucagon secretory granules. .
功能
domain:Contains a histidine-rich region, HXXXXXHNH-motif, which is a ligand for zinc.,function:Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells.,polymorphism:Variant Trp-325 is a risk factor that confers susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM) [MIM:125853].,similarity:Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.,subcellular location:Strictly associated with the insulin granule secretory.,tissue specificity:Strictly restricted to the pancreas islets cells. Found in insulin-producing beta cells and colocalized with insulin.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Western blot analysis of lysates from K562 cells, using SLC30A8 Antibody. The lane on the right is blocked with the synthesized peptide.

Western blot analysis of the lysates from HeLa cells using SLC30A8 antibody.

Western Blot analysis of K562 cells using ZnT-8 Polyclonal Antibody. Secondary antibody was diluted at 1:20000

相关文献

产品问答

相关产品

免责声明| 法律支持| 联系方式

市场:027-65023363   行政/人事:027-62439686   邮箱:marketing@brainvta.com  

销售总监:张经理  18995532642  华东区:陈经理 18013970337   华南区:王经理 13100653525   华中/西区:杨经理 18186518905   华北区:张经理 18893721749

地址:中国武汉东湖高新区光谷七路128号中科开物产业园1号楼

Copyright © 武汉枢密脑科学技术有限公司. All RIGHTS RESERVED.
鄂ICP备2021009124号 DIGITAL BY VTHINK