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ZnT-4 Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PT4989
产品名称
ZnT-4 Rabbit Polyclonal Antibody
别名
SLC30A4; ZNT4; Zinc transporter 4; ZnT-4; Solute carrier family 30 member 4
类别
常规抗体
基因名称
SLC30A4
蛋白名称
Zinc transporter 4
推荐应用
WB
反应种属
Human,Mouse,Rat
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
7782
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7782
Human Swissprot No.
O14863
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O14863/entry
Mouse Gene ID
22785
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22785
Mouse Swissprot No.
O35149
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O35149
Rat Gene ID
64469
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64469
Rat Swissprot No.
O55174
Rat Swissprot Link
http://www.uniprot.org/uniprot/O55174
免疫原
The antiserum was produced against synthesized peptide derived from human SLC30A4. AA range:71-120
特异性
ZnT-4 Polyclonal Antibody detects endogenous levels of ZnT-4 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
预测分子量
47kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
Zinc is the second most abundant trace metal in the human body. It is an essential element, serving both a structural role, as in the formation of zinc fingers in DNA-binding proteins, and a catalytic role in metalloenzymes, such as pancreatic carboxypeptidases (e.g., MIM 114852), alkaline phosphatases (e.g., MIM 171760), various dehydrogenases, and superoxide dismutases (e.g., MIM 147450). SLC30A4, or ZNT4, belongs to the ZNT family of zinc transporters. ZNTs are involved in transporting zinc out of the cytoplasm and have similar structures, consisting of 6 transmembrane domains and a histidine-rich cytoplasmic loop (Huang and Gitschier, 1997 [PubMed 9354792]).[supplied by OMIM, Mar 2008],
组织表达
Fetal brain,Malignant prostate,Mesangial cell,Testis,
细胞定位
Endosome membrane ; Multi-pass membrane protein . Late endosome membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein .
功能
domain:Contains a histidine-rich region which is a ligand for zinc and an aspartate-rich region which is a potential ligand for zinc.,function:Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular compartment.,similarity:Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunohistochemistry analysis of paraffin-embedded human lymph node tissue, using SLC30A4 Antibody. The picture on the right is blocked with the synthesized peptide.

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