产品名称
ZnT-4 Rabbit Polyclonal Antibody
别名
SLC30A4; ZNT4; Zinc transporter 4; ZnT-4; Solute carrier family 30 member 4
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7782
Human Swissprot No.
O14863
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O14863/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22785
Mouse Swissprot No.
O35149
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O35149
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64469
Rat Swissprot Link
http://www.uniprot.org/uniprot/O55174
免疫原
The antiserum was produced against synthesized peptide derived from human SLC30A4. AA range:71-120
特异性
ZnT-4 Polyclonal Antibody detects endogenous levels of ZnT-4 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
Zinc is the second most abundant trace metal in the human body. It is an essential element, serving both a structural role, as in the formation of zinc fingers in DNA-binding proteins, and a catalytic role in metalloenzymes, such as pancreatic carboxypeptidases (e.g., MIM 114852), alkaline phosphatases (e.g., MIM 171760), various dehydrogenases, and superoxide dismutases (e.g., MIM 147450). SLC30A4, or ZNT4, belongs to the ZNT family of zinc transporters. ZNTs are involved in transporting zinc out of the cytoplasm and have similar structures, consisting of 6 transmembrane domains and a histidine-rich cytoplasmic loop (Huang and Gitschier, 1997 [PubMed 9354792]).[supplied by OMIM, Mar 2008],
组织表达
Fetal brain,Malignant prostate,Mesangial cell,Testis,
细胞定位
Endosome membrane ; Multi-pass membrane protein . Late endosome membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein .
功能
domain:Contains a histidine-rich region which is a ligand for zinc and an aspartate-rich region which is a potential ligand for zinc.,function:Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular compartment.,similarity:Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
