产品名称
alpha Lactalbumin(9E9)Mouse Monoclonal Antibody
别名
Alpha-lactalbumin (Lactose synthase B protein) (Lysozyme-like protein 7)
存储缓冲液
PBS, pH 7.4, containing 0.5%BSA, 0.02% New type preservative N as Preservative and 50% Glycerol.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3906
Human Swissprot No.
P00709
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P00709/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16770
Mouse Swissprot No.
P29752
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P29752
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24528
Rat Swissprot Link
http://www.uniprot.org/uniprot/P00714
免疫原
Synthetic Peptide of alpha Lactalbumin
特异性
The antibody detects endogenous alpha Lactalbumin proteins.
稀释度
WB 1:1000 IF 1:200 IHC 1:50-300
背景介绍
This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells. [provided by RefSeq, Jul 2008],
组织表达
Mammary gland specific. Secreted in milk.
信号通路
Galactose metabolism;
功能
function:Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.,similarity:Belongs to the glycosyl hydrolase 22 family.,subunit:Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).,tissue specificity:Mammary gland specific. Secreted in milk.,
纯化
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
