产品名称
ZNF397 Rabbit Polyclonal Antibody
别名
ZNF397; ZNF47; ZSCAN15; Zinc finger protein 397; Zinc finger and SCAN domain-containing protein 15; Zinc finger protein 47
蛋白名称
Zinc finger protein 397
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84307
Human Swissprot No.
Q8NF99
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8NF99/entry
免疫原
The antiserum was produced against synthesized peptide derived from human ZNF397. AA range:10-59
特异性
ZNF397 Polyclonal Antibody detects endogenous levels of ZNF397 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
zinc finger protein 397(ZNF397) Homo sapiens This gene encodes a protein with a N-terminal SCAN domain, and the longer isoform contains nine C2H2-type zinc finger repeats in the C-terminal domain. The protein localizes to centromeres during interphase and early prophase, and different isoforms can repress or activate transcription in transfection studies. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but their biological validity has not been determined. [provided by RefSeq, Oct 2009],
组织表达
Expressed strongly in testis, moderately in skeletal muscle, pancreas and prostate, and weakly in heart, placenta, liver, kidney, spleen, thymus and small intestine.
细胞定位
[Isoform 1]: Nucleus.; [Isoform 3]: Nucleus. Cytoplasm.
功能
function:Isoform 3 acts as a DNA-dependent transcriptional repressor.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 1 SCAN box domain.,similarity:Contains 9 C2H2-type zinc fingers.,subunit:Isoforms 1 and 3 can both homo- and hetero-associate. Homo-association of isoform 1 is dependent on the presence of the SCAN domain.,tissue specificity:Expressed strongly in testis, moderately in skeletal muscle, pancreas and prostate, and weakly in heart, placenta, liver, kidney, spleen, thymus and small intestine.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
