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ZIS Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PT4952
产品名称
ZIS Rabbit Polyclonal Antibody
别名
ZRANB2; ZIS; ZNF265; Zinc finger Ran-binding domain-containing protein 2; Zinc finger protein 265; Zinc finger; splicing
类别
常规抗体
基因名称
ZRANB2
蛋白名称
Zinc finger Ran-binding domain-containing protein 2
推荐应用
WB
反应种属
Human,Mouse,Rat
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
9406
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9406
Human Swissprot No.
O95218
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O95218/entry
Mouse Gene ID
53861
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=53861
Mouse Swissprot No.
Q9R020
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9R020
Rat Gene ID
58821
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=58821
Rat Swissprot No.
O35986
Rat Swissprot Link
http://www.uniprot.org/uniprot/O35986
免疫原
The antiserum was produced against synthesized peptide derived from human ZNF265. AA range:106-155
特异性
ZIS Polyclonal Antibody detects endogenous levels of ZIS protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
预测分子量
34kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
domain:The RanBP2-type zinc fingers mediate binding to RNA.,function:Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.,PTM:Isoform 2 is phosphorylated on Ser-310 upon DNA damage, probably by ATM or ATR.,sequence caution:Intron retention.,similarity:Belongs to the ZRANB2 family.,similarity:Contains 2 RanBP2-type zinc fingers.,subunit:Interacts with the C-terminal half of SNRNP70, the Arg/Ser-rich domain of XE7 as well as with U2AF1 and CLK1.,
组织表达
Brain,Epithelium,Fetal brain,Fetal kidney,Liver,Skin,Testis,Uterus,
细胞定位
Nucleus .
功能
domain:The RanBP2-type zinc fingers mediate binding to RNA.,function:Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.,PTM:Isoform 2 is phosphorylated on Ser-310 upon DNA damage, probably by ATM or ATR.,sequence caution:Intron retention.,similarity:Belongs to the ZRANB2 family.,similarity:Contains 2 RanBP2-type zinc fingers.,subunit:Interacts with the C-terminal half of SNRNP70, the Arg/Ser-rich domain of XE7 as well as with U2AF1 and CLK1.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunofluorescence analysis of HUVEC cells, using ZNF265 Antibody. The picture on the right is blocked with the synthesized peptide.

Western blot analysis of lysates from HeLa cells, using ZNF265 Antibody. The lane on the right is blocked with the synthesized peptide.

Western Blot analysis of various cells using ZIS Polyclonal Antibody. Secondary antibody was diluted at 1:20000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).

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