产品名称
ZIP2 Rabbit Polyclonal Antibody
别名
SLC39A2; ZIP2; Zinc transporter ZIP2; 6A1; Eti-1; Solute carrier family 39 member 2; Zrt- and Irt-like protein 2; ZIP-2; hZIP2
蛋白名称
Zinc transporter ZIP2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29986
Human Swissprot No.
Q9NP94
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9NP94/entry
免疫原
The antiserum was produced against synthesized peptide derived from human SLC39A2. AA range:11-60
特异性
ZIP2 Polyclonal Antibody detects endogenous levels of ZIP2 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the ZIP family of metal ion transporters. The encoded protein functions as a zinc transporter. Mutations in this gene may be associated with susceptibility to carotid artery disease. Multiple transcript variants have been described. [provided by RefSeq, Mar 2010],
组织表达
Expressed only in prostate and uterine epithelial cells.
细胞定位
Cell membrane; Multi-pass membrane protein.
功能
function:Mediates zinc uptake. Zinc uptake may be mediated by a Zn(2+)-HCO(3)(-) symport mechanism and can function in the presence of albumin. May also transport other divalent cations. May be important in contact inhibition of normal epithelial cells and loss of its expression may play a role in tumorigenesis.,induction:Shows a dramatic induction in normal epithelial cells contact inhibition.,miscellaneous:Zinc uptake is inhibited at pH levels below 7.0 and is stimulated at higher pH and is significantly inhibited by Cu(2+), Co(2+) and Mn(2+) ions. Not inhibited by Fe(2+).,similarity:Belongs to the ZIP transporter (TC 2.A.5) family.,tissue specificity:Expressed only in prostate and uterine epithelial cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
