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ZAC1 Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PT4927
产品名称
ZAC1 Rabbit Polyclonal Antibody
别名
PLAGL1; LOT1; ZAC; Zinc finger protein PLAGL1; Lost on transformation 1; LOT-1; Pleiomorphic adenoma-like protein 1; Tumor supressor ZAC
类别
常规抗体
基因名称
PLAGL1
蛋白名称
Zinc finger protein PLAGL1
推荐应用
WB
反应种属
Human,Rat,Mouse
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
5325
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5325
Human Swissprot No.
Q9UM63
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UM63/entry
免疫原
The antiserum was produced against synthesized peptide derived from human PLAGL1. AA range:311-360
特异性
ZAC1 Polyclonal Antibody detects endogenous levels of ZAC1 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
预测分子量
50kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding two different protein isoforms. The P1 downstream promoter of this gene is imprinted, with preferential expression from the paternal allele in many tissues. [provided by RefSeq, Nov 2015],
组织表达
Colon,Fetal kidney,Lung,Mammary gland,Pituitary,Placenta,
细胞定位
Nucleus .
功能
function:Shows weak transcriptional activatory activity. Transcriptional regulator of the type 1 receptor for pituitary adenylate cyclase-activating polypeptide.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 7 C2H2-type zinc fingers.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Western blot analysis of lysates from 293 cells, using PLAGL1 Antibody. The lane on the right is blocked with the synthesized peptide.

Western blot analysis of the lysates from HeLa cells using PLAGL1 antibody.

Western Blot analysis of various cells using ZAC1 Polyclonal Antibody. Secondary antibody was diluted at 1:20000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).

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