产品名称
XRN2 Rabbit Polyclonal Antibody
别名
XRN2; 5'-3' exoribonuclease 2; DHM1-like protein; DHP protein
蛋白名称
5'-3' exoribonuclease 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22803
Human Swissprot No.
Q9H0D6
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9H0D6/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24128
Mouse Swissprot No.
Q9DBR1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9DBR1
免疫原
The antiserum was produced against synthesized peptide derived from human XRN2. AA range:81-130
特异性
XRN2 Polyclonal Antibody detects endogenous levels of XRN2 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015],
组织表达
Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2 is expressed predominantly in peripheral blood leukocytes.
细胞定位
Nucleus, nucleolus .
功能
catalytic activity:Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 5'-phosphates.,function:Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription.,similarity:Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.,similarity:Contains 1 CCHC-type zinc finger.,tissue specificity:Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2 is expressed predominantly in peripheral blood leukocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
