产品名称
XRCC3 Rabbit Polyclonal Antibody
别名
XRCC3; DNA repair protein XRCC3; X-ray repair cross-complementing protein 3
蛋白名称
DNA repair protein XRCC3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7517
Human Swissprot No.
O43542
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O43542/entry
Mouse Swissprot No.
Q9CXE6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9CXE6
免疫原
The antiserum was produced against synthesized peptide derived from human XRCC3. AA range:41-90
特异性
XRCC3 Polyclonal Antibody detects endogenous levels of XRCC3 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008],
组织表达
Cerebellum,Cervix carcinoma,Lymph,Muscle,Neuroblastoma,Placenta,
细胞定位
Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Accumulates in discrete nuclear foci prior to DNA damage, and these foci persist throughout the time course of DNA repair.
信号通路
Homologous recombination;
功能
disease:Met-241 is associated with the development of cutaneous malignant melanoma.,function:Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the recA family. RAD51 subfamily.,subunit:Interacts with RAD51C and RAD51. Part of a complex consisting of RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
