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XRCC2 Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PT4918
产品名称
XRCC2 Rabbit Polyclonal Antibody
别名
XRCC2; DNA repair protein XRCC2; X-ray repair cross-complementing protein 2
类别
常规抗体
基因名称
XRCC2
蛋白名称
DNA repair protein XRCC2
推荐应用
WB
反应种属
Human,Rat,Mouse
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
7516
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7516
Human Swissprot No.
O43543
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O43543/entry
Mouse Swissprot No.
Q9CX47
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9CX47
免疫原
The antiserum was produced against synthesized peptide derived from human XRCC2. AA range:211-260
特异性
XRCC2 Polyclonal Antibody detects endogenous levels of XRCC2 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
预测分子量
32kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. [provided by RefSeq, Jul 2008],
组织表达
Brain,Cervix carcinoma,Testis,
细胞定位
Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome .
信号通路
Homologous recombination;
功能
function:Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the recA family. RAD51 subfamily.,subunit:Interacts with RAD51D. Part of a BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2. Part of a complex consisting of RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3. In the absence of DNA, XRCC2-RAD51D formed a multimeric ring structure. In the presence of single-stranded DNA, XRCC2-RAD51D formed a filamentous structure.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using XRCC2 Antibody. The picture on the right is blocked with the synthesized peptide.

Western Blot analysis of various cells using XRCC2 Polyclonal Antibody diluted at 1:2000. Secondary antibody was diluted at 1:20000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).

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