产品名称
XRCC2 Rabbit Polyclonal Antibody
别名
XRCC2; DNA repair protein XRCC2; X-ray repair cross-complementing protein 2
蛋白名称
DNA repair protein XRCC2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7516
Human Swissprot No.
O43543
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O43543/entry
Mouse Swissprot No.
Q9CX47
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9CX47
免疫原
The antiserum was produced against synthesized peptide derived from human XRCC2. AA range:211-260
特异性
XRCC2 Polyclonal Antibody detects endogenous levels of XRCC2 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. [provided by RefSeq, Jul 2008],
组织表达
Brain,Cervix carcinoma,Testis,
细胞定位
Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome .
信号通路
Homologous recombination;
功能
function:Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the recA family. RAD51 subfamily.,subunit:Interacts with RAD51D. Part of a BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2. Part of a complex consisting of RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3. In the absence of DNA, XRCC2-RAD51D formed a multimeric ring structure. In the presence of single-stranded DNA, XRCC2-RAD51D formed a filamentous structure.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
