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XRCC1 Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PT4917
产品名称
XRCC1 Rabbit Polyclonal Antibody
别名
XRCC1; DNA repair protein XRCC1; X-ray repair cross-complementing protein 1
类别
常规抗体
基因名称
XRCC1
蛋白名称
DNA repair protein XRCC1
推荐应用
WB
反应种属
Human,Mouse,Rat
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
7515
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7515
Human Swissprot No.
P18887
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P18887/entry
Mouse Gene ID
22594
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22594
Mouse Swissprot No.
Q60596
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q60596
Rat Gene ID
84495
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84495
Rat Swissprot No.
Q9ESZ0
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9ESZ0
免疫原
The antiserum was produced against synthesized peptide derived from human XRCC1. AA range:517-566
特异性
XRCC1 Polyclonal Antibody detects endogenous levels of XRCC1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
预测分子量
70kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008],
组织表达
Expressed in fibroblasts, retinal pigmented epithelial cells and lymphoblastoid cells (at protein level).
细胞定位
Nucleus . Moves from the nucleoli to the global nuclear chromatin upon DNA damage. .
信号通路
Base excision repair;
功能
function:Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.,polymorphism:Carriers of the polymorphic Gln-399 allele may be at greater risk for tobacco- and age-related DNA damage.,PTM:Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.,PTM:Sumoylated.,similarity:Contains 2 BRCT domains.,subcellular location:Accumulates at sites of DNA damage.,subunit:Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using XRCC1 Antibody. The picture on the right is blocked with the synthesized peptide.

Western blot analysis of lysates from Jurkat cells, using XRCC1 Antibody. The lane on the right is blocked with the synthesized peptide.

Western Blot analysis of various cells using XRCC1 Polyclonal Antibody diluted at 1:1000. Secondary antibody was diluted at 1:20000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).

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