产品名称
XRCC1 Rabbit Polyclonal Antibody
别名
XRCC1; DNA repair protein XRCC1; X-ray repair cross-complementing protein 1
蛋白名称
DNA repair protein XRCC1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7515
Human Swissprot No.
P18887
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P18887/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22594
Mouse Swissprot No.
Q60596
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q60596
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84495
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9ESZ0
免疫原
The antiserum was produced against synthesized peptide derived from human XRCC1. AA range:517-566
特异性
XRCC1 Polyclonal Antibody detects endogenous levels of XRCC1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008],
组织表达
Expressed in fibroblasts, retinal pigmented epithelial cells and lymphoblastoid cells (at protein level).
细胞定位
Nucleus . Moves from the nucleoli to the global nuclear chromatin upon DNA damage. .
信号通路
Base excision repair;
功能
function:Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.,polymorphism:Carriers of the polymorphic Gln-399 allele may be at greater risk for tobacco- and age-related DNA damage.,PTM:Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.,PTM:Sumoylated.,similarity:Contains 2 BRCT domains.,subcellular location:Accumulates at sites of DNA damage.,subunit:Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
