产品名称
XPLN Rabbit Polyclonal Antibody
别名
ARHGEF3; Rho guanine nucleotide exchange factor 3; Exchange factor found in platelets and leukemic and neuronal tissues; XPLN
蛋白名称
Rho guanine nucleotide exchange factor 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=50650
Human Swissprot No.
Q9NR81
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9NR81/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=71704
Mouse Swissprot No.
Q91X46
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91X46
免疫原
The antiserum was produced against synthesized peptide derived from human ARHGEF3. AA range:456-505
特异性
XPLN Polyclonal Antibody detects endogenous levels of XPLN protein.
稀释度
WB 1:500 - 1:2000.IHC-p:1:50-300 ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Widely expressed. Highest levels are found in adult brain and skeletal muscle. Lower levels are found in heart and kidney.
信号通路
Regulation of Actin Dynamics; AMPK
功能
function:Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,subunit:Interacts with RHOA and RHOB.,tissue specificity:Widely expressed. Highest levels are found in adult brain and skeletal muscle. Lower levels are found in heart and kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
