产品名称
X11γ Rabbit Polyclonal Antibody
别名
APBA3; MINT3; X11L2; Amyloid beta A4 precursor protein-binding family A member 3; Adapter protein X11gamma; Neuron-specific X11L2 protein; Neuronal Munc18-1-interacting protein 3; Mint-3
蛋白名称
Amyloid beta A4 precursor protein-binding family A member 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9546
Human Swissprot No.
O96018
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O96018/entry
Mouse Swissprot No.
O88888
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O88888
免疫原
The antiserum was produced against synthesized peptide derived from human APBA3. AA range:361-410
特异性
X11γ Polyclonal Antibody detects endogenous levels of X11γ protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
amyloid beta precursor protein binding family A member 3(APBA3) Homo sapiens The protein encoded by this gene is a member of the X11 protein family. It is an adapter protein that interacts with the Alzheimer's disease amyloid precursor protein. This gene product is believed to be involved in signal transduction processes. This gene is a candidate gene for Alzheimer's disease. [provided by RefSeq, Jul 2008],
组织表达
Expressed in all tissues examined with lower levels in brain and testis.
细胞定位
Cytoplasm, perinuclear region .
功能
domain:Composed of an N-terminal domain, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the beta-amyloid precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.,function:May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 PID domain.,similarity:Contains 2 PDZ (DHR) domains.,subunit:Binds to the cytoplasmic domain of amyloid protein (APP) in vivo.,tissue specificity:Expressed in all the tissues examined with lower levels in brain and testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
