产品名称
WWOX Rabbit Polyclonal Antibody
别名
WWOX; FOR; WOX1; WW domain-containing oxidoreductase; Fragile site FRA16D oxidoreductase
蛋白名称
WW domain-containing oxidoreductase
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51741
Human Swissprot No.
Q9NZC7
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9NZC7/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80707
Mouse Swissprot No.
Q91WL8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91WL8
免疫原
The antiserum was produced against synthesized peptide derived from human WWOX. AA range:1-50
特异性
WWOX Polyclonal Antibody detects endogenous levels of WWOX protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
WWOX (WW domain containing oxidoreductase) encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. WWOX spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of WWOX is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants.
组织表达
Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines.
细胞定位
Cytoplasm . Nucleus . Mitochondrion . Golgi apparatus . Partially localizes to the mitochondria (PubMed:14695174). Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity). Translocates to the nucleus in response to TGFB1 (PubMed:19366691). Isoform 5 and isoform 6 may localize in the nucleus. .
功能
skeletal system development,?ossification,?osteoblast differentiation,?induction of apoptosis,?steroid metabolic process,?negative regulation of signal transduction,?negative regulation of cell communication,?regulation of cell death,positive regulation of cell death,?induction of programmed cell death,?regulation of Wnt receptor signaling pathway,negative regulation of Wnt receptor signaling pathway,?regulation of apoptosis,?positive regulation of apoptosis,regulation of programmed cell death,?positive regulation of programmed cell death,?skeletal system morphogenesis,oxidation reduction,?bone development,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
