产品名称
Wnt-1 Rabbit Polyclonal Antibody
别名
WNT1; INT1; Proto-oncogene Wnt-1; Proto-oncogene Int-1 homolog
蛋白名称
Proto-oncogene Wnt-1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7471
Human Swissprot No.
P04628
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P04628/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22408
Mouse Swissprot No.
P04426
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P04426
免疫原
The antiserum was produced against synthesized peptide derived from human WNT1. AA range:301-350
特异性
Wnt-1 Polyclonal Antibody detects endogenous levels of Wnt-1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in
细胞定位
Secreted, extracellular space, extracellular matrix . Secreted .
信号通路
WNT;WNT-T CELLHedgehog;Melanogenesis;Pathways in cancer;Basal cell carcinoma;
功能
function:Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters.,similarity:Belongs to the Wnt family.,subunit:Interacts with PORCN. Interacts with RSPO1, RSPO2 and RSPO3.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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