产品名称
IL1AP Rabbit Polyclonal Antibody
别名
Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP) (Interleukin-1 receptor 3) (IL-1R-3) (IL-1R3)
基因名称
IL1RAP C3orf13 IL1R3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.183% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/3556
Human Swissprot No.
Q9NPH3
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NPH3/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/16180
Mouse Swissprot No.
Q61730
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q61730
Rat Gene Link
https://www.uniprot.org/uniprot/25466
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q63621
免疫原
Synthesized peptide derived from human IL1AP AA range: 213-263
特异性
This antibody detects endogenous levels of IL1AP at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Nov 2009],
组织表达
Detected in liver, skin, placenta, thymus and lung. Isoform 4 is predominantly expressed in brain. Overexpressed on candidate chronic myeloid leukemia (CML) stem cells, hematopoietic stem cells and mononuclear cells of patients with acute myeloid leukemia (AML). Overexpressed in patients with chronic obstructive pulmonary disease (COPD). Expressed in T-helper 1 (Th1) and T-helper 2 (Th2) cell subsets (PubMed:10653850).
细胞定位
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.
功能
function:Mediates interleukin-1-dependent activation of NF-kappa-B. Isoform 1 is part of the membrane-bound form of the IL-1 receptor. Signaling involves formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 or IRAK2. Isoform 2 modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor.,induction:Phorbol ester treatment causes down-regulation of isoform 1 and induction of isoform 2.,similarity:Belongs to the interleukin-1 receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Detected in liver, skin, placenta, thymus and lung.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
