产品名称
Wee 2 Rabbit Polyclonal Antibody
别名
WEE2; WEE1B; Wee1-like protein kinase 2; Wee1-like protein kinase 1B; Wee1B kinase
蛋白名称
Wee1-like protein kinase 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=494551
Human Swissprot No.
P0C1S8
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P0C1S8/entry
Mouse Swissprot No.
Q66JT0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q66JT0
免疫原
The antiserum was produced against synthesized peptide derived from human WEE2. AA range:151-200
特异性
Wee 2 Polyclonal Antibody detects endogenous levels of Wee 2 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Phosphorylates and inhibits CDC2. May act as a negative regulator of entry into mitosis (G2 to M transition).,PTM:Phosphorylated .,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Expressed in testis.,
组织表达
Expressed in oocytes (at protein level) (PubMed:29606300). May also be expressed in testis (PubMed:11029659).
信号通路
Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;
功能
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Phosphorylates and inhibits CDC2. May act as a negative regulator of entry into mitosis (G2 to M transition).,PTM:Phosphorylated .,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Expressed in testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
