产品名称
WDHD1 Rabbit Polyclonal Antibody
别名
WDHD1; AND1; WD repeat and HMG-box DNA-binding protein 1; Acidic nucleoplasmic DNA-binding protein 1; And-1
蛋白名称
WD repeat and HMG-box DNA-binding protein 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11169
Human Swissprot No.
O75717
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O75717/entry
Mouse Swissprot No.
P59328
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P59328
免疫原
The antiserum was produced against synthesized peptide derived from human WDHD1. AA range:721-770
特异性
WDHD1 Polyclonal Antibody detects endogenous levels of WDHD1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene contains multiple N-terminal WD40 domains and a C-terminal high mobility group (HMG) box. WD40 domains are found in a variety of eukaryotic proteins and may function as adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
组织表达
Embryonal rhabdomyosarcoma,Epithelium,Fetal brain,Liver,Ski
细胞定位
Nucleus, nucleoplasm .
功能
caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Binds DNA with high affinity. May also be involved in protein-protein interactions.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 HMG box DNA-binding domain.,similarity:Contains 7 WD repeats.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
