产品名称
WAVE3 Rabbit Polyclonal Antibody
别名
WASF3; KIAA0900; SCAR3; WAVE3; Wiskott-Aldrich syndrome protein family member 3; WASP family protein member 3; Protein WAVE-3; Verprolin homology domain-containing protein 3
蛋白名称
Wiskott-Aldrich syndrome protein family member 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10810
Human Swissprot No.
Q9UPY6
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UPY6/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=245880
Mouse Swissprot No.
Q8VHI6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8VHI6
免疫原
The antiserum was produced against synthesized peptide derived from human WASF3. AA range:151-200
特异性
WAVE3 Polyclonal Antibody detects endogenous levels of WAVE3 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. A pseudogene of this gene have been defined on chromosome 6. Alternative splicing results in multiple transcript variants [provided by RefSeq, May 2014],
组织表达
Expressed in ovary and brain.
细胞定位
Cytoplasm, cytoskeleton.
信号通路
Adherens_Junction;Fc gamma R-mediated phagocytosis;
功能
domain:Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.,function:Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton.,similarity:Belongs to the SCAR/WAVE family.,similarity:Contains 1 WH2 domain.,subunit:Binds actin and the Arp2/3 complex.,tissue specificity:Expressed in ovary and brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
