产品名称
v-SNARE Vti1a Rabbit Polyclonal Antibody
别名
VTI1A; Vesicle transport through interaction with t-SNAREs homolog 1A; Vesicle transport v-SNARE protein Vti1-like 2; Vti1-rp2
蛋白名称
Vesicle transport through interaction with t-SNAREs homolog 1A
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=143187
Human Swissprot No.
Q96AJ9
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q96AJ9/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=53611
Mouse Swissprot No.
O89116
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O89116
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=65277
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9JI51
免疫原
The antiserum was produced against synthesized peptide derived from human VTI1A. AA range:31-80
特异性
v-SNARE Vti1a Polyclonal Antibody detects endogenous levels of v-SNARE Vti1a protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the family of soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptors (SNAREs) that function in intracellular trafficking. This family member is involved in vesicular transport between endosomes and the trans-Golgi network. It is a vesicle-associated SNARE (v-SNARE) that interacts with target membrane SNAREs (t-SNAREs). Polymorphisms in this gene have been associated with binocular function, and also with susceptibility to colorectal and lung cancers. A recurrent rearrangement has been found between this gene and the transcription factor 7-like 2 (TCF7L2) gene in colorectal cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],
细胞定位
Cytoplasmic vesicle . Golgi apparatus membrane ; Single-pass type IV membrane protein .
信号通路
SNARE interactions in vesicular transport;
功能
function:V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence.,similarity:Belongs to the VTI1 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
