产品名称
VRK3 Rabbit Polyclonal Antibody
别名
VRK3; Inactive serine/threonine-protein kinase VRK3; Serine/threonine-protein pseudokinase VRK3; Vaccinia-related kinase 3
蛋白名称
Inactive serine/threonine-protein kinase VRK3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51231
Human Swissprot No.
Q8IV63
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8IV63/entry
Mouse Swissprot No.
Q8K3G5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8K3G5
免疫原
Synthesized peptide derived from the Internal region of human VRK3.
特异性
VRK3 Polyclonal Antibody detects endogenous levels of VRK3 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
vaccinia related kinase 3(VRK3) Homo sapiens This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. In both human and mouse, this gene has substitutions at several residues within the ATP binding motifs that in other kinases have been shown to be required for catalysis. In vitro assays indicate the protein lacks phosphorylation activity. The protein, however, likely retains its substrate binding capability. This gene is widely expressed in human tissues and its protein localizes to the nucleus. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008],
组织表达
Brain,Liver,Skin,Testis,Trachea,
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Probable serine/threonine kinase.,similarity:Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.,similarity:Contains 1 protein kinase domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.