产品名称
VRK2 Rabbit Polyclonal Antibody
别名
VRK2; Serine/threonine-protein kinase VRK2; Vaccinia-related kinase 2
蛋白名称
Serine/threonine-protein kinase VRK2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7444
Human Swissprot No.
Q86Y07
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q86Y07/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=69922
Mouse Swissprot No.
Q8BN21
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BN21
免疫原
The antiserum was produced against synthesized peptide derived from human VRK2. AA range:171-220
特异性
VRK2 Polyclonal Antibody detects endogenous levels of VRK2 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
vaccinia related kinase 2(VRK2) Homo sapiens This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity. [provided by RefSeq, Jan 2014],
组织表达
Isoform 1 and isoform 2 are expressed in various tumor cell lines. Expression of isoform 1 inversely correlates with ERBB2 in breast carcinomas (at protein level). Widely expressed. Highly expressed in fetal liver, skeletal muscle, pancreas, heart, peripheral blood leukocytes and testis.
细胞定位
[Isoform 1]: Cytoplasm . Endoplasmic reticulum membrane ; Single-pass type IV membrane protein . Mitochondrion membrane ; Single-pass type IV membrane protein . Nucleus envelope .; [Isoform 2]: Cytoplasm . Nucleus .
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Probable serine/threonine kinase.,similarity:Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Widely expressed. Highly expressed in fetal liver, skeletal muscle, pancreas, heart, peripheral blood leukocytes and testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
