BD-PT4872-VEGF-D Rabbit Polyclonal Antibody-现货抗体产品库武汉枢密脑科学技术有限公司

VEGF-D Rabbit Polyclonal Antibody

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产品基本信息

产品货号

BD-PT4872

产品名称

VEGF-D Rabbit Polyclonal Antibody

别名

FIGF; VEGFD; Vascular endothelial growth factor D; VEGF-D; c-Fos-induced growth factor; FIGF

类别

常规抗体

基因名称

FIGF

蛋白名称

Vascular endothelial growth factor D

推荐应用

反应种属

Human,Mouse,Rat,Monkey

浓度

1 mg/ml

存储缓冲液

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

Human Gene ID

2277

Human Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2277

Human Swissprot No.

O43915

Human Swissprot Link

http://www.uniprot.org/uniprotkb/O43915/entry

Mouse Gene ID

14205

Mouse Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14205

Mouse Swissprot No.

P97946

Mouse Swissprot Link

http://www.uniprot.org/uniprot/P97946

Rat Gene ID

360457

Rat Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=360457

Rat Swissprot No.

O35251

Rat Swissprot Link

http://www.uniprot.org/uniprot/O35251

免疫原

The antiserum was produced against synthesized peptide derived from human VEGF-D. AA range:153-202

特异性

VEGF-D Polyclonal Antibody detects endogenous levels of VEGF-D protein.

稀释度

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

预测分子量

35kD

运输及保存条件

-20°C/1 year

宿主

Polyclonal, Rabbit,IgG

背景介绍

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011],

组织表达

Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas.

细胞定位

Secreted.

信号通路

Cytokine-cytokine receptor interaction;mTOR;Focal adhesion;Pathways in cancer;Renal cell carcinoma;Pancreatic cancer;Bladder cancer;

功能

function:Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (Flk1) and VEGFR-3 (Flt4) receptors.,PTM:Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.,similarity:Belongs to the PDGF/VEGF growth factor family.,subunit:Homodimer; non-covalent and antiparallel.,tissue specificity:Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas.,

期货

现货

纯化

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunohistochemistry analysis of VEGF-D antibody in paraffin-embedded human lung carcinoma tissue.

Western blot analysis of lysate from COS-7 cells, using VEGF-D antibody.

Western Blot analysis of various cells using VEGF-D Polyclonal Antibody. Secondary antibody was diluted at 1:20000

Immunohistochemical analysis of paraffin-embedded Human lung. 1, Antibody was diluted at 1:100（4°,overnight）. 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200（room temperature, 30min）.

Immunohistochemical analysis of paraffin-embedded Human testis. 1, Antibody was diluted at 1:200（4°,overnight）. 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200（room temperature, 30min）.