BD-PT4871

VEGF-B Rabbit Polyclonal Antibody

VEGFB; VRF; Vascular endothelial growth factor B; VEGF-B; VEGF-related factor; VRF

常规抗体

VEGFB

Vascular endothelial growth factor B

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

7423

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7423

P49765

http://www.uniprot.org/uniprotkb/P49765/entry

22340

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22340

P49766

http://www.uniprot.org/uniprot/P49766

89811

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=89811

O35485

http://www.uniprot.org/uniprot/O35485

The antiserum was produced against synthesized peptide derived from human VEGFB. AA range:91-140

VEGF-B Polyclonal Antibody detects endogenous levels of VEGF-B protein.

WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000. IF 1:100-300 Not yet tested in other applications.

21kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011],

Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.

Secreted. Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.

Cytokine-cytokine receptor interaction;mTOR;Focal adhesion;Pathways in cancer;Renal cell carcinoma;Pancreatic cancer;Bladder cancer;

alternative products:Additional isoforms seem to exist,function:Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.,PTM:VEGF-B186 is O-glycosylated.,similarity:Belongs to the PDGF/VEGF growth factor family.,subcellular location:Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.,subunit:Homodimer; disulfide-linked. Can also form heterodimer with VEGF.,tissue specificity:Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.