产品名称
S47A1 Rabbit Polyclonal Antibody
别名
Multidrug and toxin extrusion protein 1 (MATE-1) (hMATE-1) (Solute carrier family 47 member 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.186% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/55244
Human Swissprot No.
Q96FL8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96FL8/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/67473
Mouse Swissprot No.
Q8K0H1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K0H1
Rat Gene Link
https://www.uniprot.org/uniprot/360539
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5I0E9
免疫原
Synthesized peptide derived from human S47A1 AA range: 158-208
特异性
This antibody detects endogenous levels of S47A1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function. [provided by RefSeq, Jul 2008],
组织表达
Expressed in adrenal gland, and to a lower extent in liver, skeletal muscle and kidney (especially found in luminal membranes of the urinary tubules, bile caniculi and brush border membranes).
细胞定位
Cell membrane ; Multi-pass membrane protein . Predominantly localized at the plasma membrane but also found in intracellular organelles.
功能
function:Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes.,similarity:Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.,subcellular location:Predominantly localized at the plasma membrane but also found in intracellular organelles.,tissue specificity:Expressed in adrenal gland, and to a lower extent in liver, skeletal muscle and kidney (especially found in luminal membranes of the urinary tubules, bile caniculi and brush border membranes).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
