产品名称
STAU2 Rabbit Polyclonal Antibody
别名
Double-stranded RNA-binding protein Staufen homolog 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.187% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/27067
Human Swissprot No.
Q9NUL3
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NUL3/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/29819
Mouse Swissprot No.
Q8CJ67
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CJ67
Rat Gene Link
https://www.uniprot.org/uniprot/171500
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q68SB1
免疫原
Synthesized peptide derived from human STAU2 AA range: 75-125
特异性
This antibody detects endogenous levels of STAU2 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009],
组织表达
Amygdala,Brain,Cerebellum,Epithelium,Ovary,PCR rescued clones,Placenta,Retina,Teratocarcinoma,Thalamus,Thymus,Trachea,Urinary bladder carcinoma,
细胞定位
Cytoplasm. Nucleus. Nucleus, nucleolus. Endoplasmic reticulum. Shuttles between the nucleolus, nucleus and the cytoplasm. Nuclear export of isoform 1 is independent of XPO1/CRM1 and requires the exportin XPO5. Nuclear export of isoform 2 and isoform 3 can occur by both XPO1/CRM1-dependent and XPO1/CRM1-independent pathways. Found in large cytoplasmic ribonucleoprotein (RNP) granules which are present in the actin rich regions of myelinating processes and associated with microtubules, polysomes and the endoplasmic reticulum. Also recruited to stress granules (SGs) upon inhibition of translation or oxidative stress. These structures are thought to harbor housekeeping mRNAs when translation is aborted (By similarity). .
功能
domain:The DRBM 3 domain appears to be the major RNA-binding determinant. This domain also mediates interaction with XPO5 and is required for XPO1/CRM1-independent nuclear export.,function:RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body.,similarity:Contains 4 DRBM (double-stranded RNA-binding) domains.,subcellular location:Shuttles between the nucleolus, nucleus and the cytoplasm. Nuclear export of isoform 1 is independent of XPO1/CRM1 and requires the exportin XPO5. Nuclear export of isoform 2 and isoform 3 can occur by both XPO1/CRM1-dependent and XPO1/CRM1-independent pathways. Found in large cytoplasmic ribonucleoprotein (RNP) granules which are present in the actin rich regions of myelinating processes and associated with microtubules, polysomes and the endoplasmic reticulum. Also recruited to stress granules (SGs) upon inhibition of translation or oxidative stress. These structures are thought to harbor housekeeping mRNAs when translation is aborted.,subunit:Interacts with the exportin XPO5. This requires RNA and RAN bound to GTP. Interacts with microtubules. Isoform 2 and isoform 3 may also interact with ribosomes, and this association is independent of translation.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
