产品名称
VAMP-1/2/3 Rabbit Polyclonal Antibody
别名
VAMP1; SYB1; Vesicle-associated membrane protein 1; VAMP-1; Synaptobrevin-1; VAMP2; SYB2; Vesicle-associated membrane protein 2; VAMP-2; Synaptobrevin-2; VAMP3; SYB3; Vesicle-associated membrane protein 3; VAMP-3; Cellubrevin; CEB; Synaptob
蛋白名称
Vesicle-associated membrane protein 1/2/3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
6843/6844/9341
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6843
Human Swissprot No.
P23763/P63027/Q15836
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P23763/entry
Mouse Gene ID
22317/22318/22319
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22317
Rat Gene ID
25624/24803/29528
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25624
Rat Swissprot No.
Q63666/P63045/P63025
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q63666
免疫原
The antiserum was produced against synthesized peptide derived from human VAMP-1/2/3. AA range:21-70
特异性
VAMP-1/2/3 Polyclonal Antibody detects endogenous levels of VAMP-1/2/3 protein.
稀释度
WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:10000. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2014],
组织表达
Nervous system, skeletal muscle and adipose tissue.
细胞定位
[Isoform 1]: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass type IV membrane protein . Cell junction, synapse, synaptosome .; [Isoform 2]: Cytoplasmic vesicle membrane ; Single-pass type IV membrane protein . Cell junction, synapse, synaptosome .; [Isoform 3]: Mitochondrion outer membrane; Single-pass type IV membrane protein .
信号通路
SNARE interactions in vesicular transport;
功能
function:Involved in the targeting and/or fusion of transport vesicles to their target membrane.,similarity:Belongs to the synaptobrevin family.,similarity:Contains 1 v-SNARE coiled-coil homology domain.,subunit:Interacts with VAPA and VAPB.,tissue specificity:Nervous system, skeletal muscle and adipose tissue.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
