产品名称
VPS45 Rabbit Polyclonal Antibody
别名
Vacuolar protein sorting-associated protein 45 (h-VPS45) (hlVps45)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.188% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/11311
Human Swissprot No.
Q9NRW7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NRW7/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/22365
Mouse Swissprot No.
P97390
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P97390
Rat Gene Link
https://www.uniprot.org/uniprot/64516
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O08700
免疫原
Synthesized peptide derived from human VPS45 AA range: 470-520
特异性
This antibody detects endogenous levels of VPS45 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013],
组织表达
Ubiquitous. Expression was highest in testis, heart and brain, intermediate in kidney, spleen, prostate, ovary, small intestine and thymus and low in lung, skeletal muscle, placenta, colon, pancreas, peripheral blood leukocytes and liver.
细胞定位
Golgi apparatus membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Associated with Golgi/endosomal vesicles and the trans-Golgi network. .
功能
function:May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network.,similarity:Belongs to the STXBP/unc-18/SEC1 family.,subcellular location:Associated with Golgi/endosomal vesicles and the trans-Golgi network.,subunit:Interacts with STX6 (By similarity). Interacts with ZFYVE20.,tissue specificity:Ubiquitous. Expression was highest in testis, heart and brain, intermediate in kidney, spleen, prostate, ovary, small intestine and thymus and low in lung, skeletal muscle, placenta, colon, pancreas, peripheral blood leukocytes and liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
