产品名称
USP48 Rabbit Polyclonal Antibody
别名
USP48; USP31; Ubiquitin carboxyl-terminal hydrolase 48; Deubiquitinating enzyme 48; Ubiquitin thioesterase 48; Ubiquitin-specific-processing protease 48
蛋白名称
Ubiquitin carboxyl-terminal hydrolase 48
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84196
Human Swissprot No.
Q86UV5
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q86UV5/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=170707
Mouse Swissprot No.
Q3V0C5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q3V0C5
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=362636
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q76LT8
免疫原
The antiserum was produced against synthesized peptide derived from human USP48. AA range:631-680
特异性
USP48 Polyclonal Antibody detects endogenous levels of USP48 protein.
稀释度
WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],
细胞定位
Cytoplasm . Nucleus .
功能
catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,caution:Was named USP31 by some authors (PubMed:15354349 and PubMed:17081983).,function:Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at post-synaptic sites.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 ubiquitin-like domain.,similarity:Contains 3 DUSP domains.,subunit:Interacts with TRAF2 and RELA.,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
