BD-PM3060-CD21(2C5)Mouse Monoclonal Antibody-现货抗体产品库武汉枢密脑科学技术有限公司

CD21(2C5)Mouse Monoclonal Antibody

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产品基本信息

产品货号

BD-PM3060

产品名称

CD21(2C5)Mouse Monoclonal Antibody

别名

CR2; C3DR; Complement receptor type 2; Cr2; Complement C3d receptor; Epstein-Barr virus receptor; EBV receptor; CD21

类别

常规抗体

基因名称

CR2

蛋白名称

Complement receptor type 2

推荐应用

反应种属

Human,Mouse,Rat

存储缓冲液

PBS, pH 7.4, containing 0.5%BSA, 0.02% New type preservative N as Preservative and 50% Glycerol.

Human Gene ID

1380

Human Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1380

Human Swissprot No.

P20023

Human Swissprot Link

http://www.uniprot.org/uniprotkb/P20023/entry

Mouse Swissprot No.

P19070

Mouse Swissprot Link

http://www.uniprot.org/uniprot/P19070

Rat Swissprot Link

http://www.uniprot.org/uniprot/

免疫原

Synthetic Peptide of CD21

特异性

The antibody detects endogenous CD21 proteins.

稀释度

IHC 1:200 IF 1:50-200

预测分子量

113kD

运输及保存条件

-20°C/1 year

宿主

Monoclonal, Mouse

背景介绍

This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009],

组织表达

Mature B-lymphocytes, T-lymphocytes, pharyngeal epithelial cells, astrocytes and follicular dendritic cells of the spleen.

细胞定位

Cell membrane ; Single-pass type I membrane protein.

信号通路

Complement and coagulation cascades;Hematopoietic cell lineage;B_Cell_Antigen;

功能

disease:Genetic variations in CR2 are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9) [MIM:610927]. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.,function:Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation.,similarity:Belongs to the receptors of complement activation (RCA) family.,similarity:Contains 15 Sushi (CCP/SCR) domains.,tissue specificity:Mature B-lymphocytes, T-lymphocytes, pharyngeal epithelial cells, astrocytes and follicular dendritic cells of the spleen.,

期货

现货

纯化

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Immunohistochemical analysis of paraffin-embedded Human-stomach tissue. 1,CD21 Monoclonal Antibody（2C5） was diluted at 1:200（4°C,overnight）. 2, Sodium citrate pH 6.0 was used for antibody retrieval（>98°C,20min）. 3,Secondary antibody was diluted at 1:200（room tempeRature, 30min）. Negative control was used by secondary antibody only.

Immunohistochemical analysis of paraffin-embedded Rat-kidney tissue. 1,CD21 Monoclonal Antibody（2C5） was diluted at 1:200（4°C,overnight）. 2, Sodium citrate pH 6.0 was used for antibody retrieval（>98°C,20min）. 3,Secondary antibody was diluted at 1:200（room tempeRature, 30min）. Negative control was used by secondary antibody only.

Immunohistochemical analysis of paraffin-embedded Mouse-kidney tissue. 1,CD21 Monoclonal Antibody（2C5） was diluted at 1:200（4°C,overnight）. 2, Sodium citrate pH 6.0 was used for antibody retrieval（>98°C,20min）. 3,Secondary antibody was diluted at 1:200（room tempeRature, 30min）. Negative control was used by secondary antibody only.

Immunofluorescence analysis of Mouse-liver tissue. 1,CD21 Monoclonal Antibody（2C5）（red） was diluted at 1:200（4°C,overnight）. 2, Cy3 labled Secondary antibody was diluted at 1:300（room temperature, 50min）.3, Picture B: DAPI（blue） 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B

IHC staining of human tonsil tissue, diluted at 1:200.