产品名称
USP45 Rabbit Polyclonal Antibody
别名
USP45; Ubiquitin carboxyl-terminal hydrolase 45; Deubiquitinating enzyme 45; Ubiquitin thioesterase 45; Ubiquitin-specific-processing protease 45
蛋白名称
Ubiquitin carboxyl-terminal hydrolase 45
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=85015
Human Swissprot No.
Q70EL2
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q70EL2/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=77593
Mouse Swissprot No.
Q8K387
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8K387
免疫原
The antiserum was produced against synthesized peptide derived from human USP45. AA range:301-350
特异性
USP45 Polyclonal Antibody detects endogenous levels of USP45 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a deubiquitylase that binds ERCC1, the catalytic subunit of the XPF-ERCC1 DNA repair endonuclease. This endonuclease is a critical regulator of DNA repair processes, and the deubiquitylase activity of the encoded protein is important for maintaining the DNA repair ability of XPF-ERCC1. [provided by RefSeq, Sep 2016],
组织表达
Widely expressed. High expression is detected in the cerebellum. In the eye, it is expressed at high levels in the optic nerve, sclera and retina, with relatively low levels in the choroid, lens and retinal pigment epithelium (PubMed:30573563).
细胞定位
Photoreceptor inner segment . Cytoplasm . Nucleus .
功能
catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 UBP-type zinc finger.,tissue specificity:Broadly expressed, with highest levels in ovary, skeletal muscle and spleen.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
