BD-PT4831

USP16 Rabbit Polyclonal Antibody

USP16; MSTP039; Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-processing protease UBP-M; Ubiquitin-specific-processing protease 16

常规抗体

USP16

Ubiquitin carboxyl-terminal hydrolase 16

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

10600

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10600

Q9Y5T5

http://www.uniprot.org/uniprotkb/Q9Y5T5/entry

74112

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=74112

Q99LG0

http://www.uniprot.org/uniprot/Q99LG0

288306

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=288306

Q2KJ09

http://www.uniprot.org/uniprot/Q2KJ09

Synthesized peptide derived from the Internal region of human USP16.

USP16 Polyclonal Antibody detects endogenous levels of USP16 protein.

WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

93kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],

Present in all the tissues examined including fetal brain, lung, liver, kidney, and adult heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Nucleus .

catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,disease:A chromosomal aberration involving USP16 is a cause of Chronic myelomonocytic leukemia. Inversion inv(21) (q21;q22) with RUNX1/AML1.,domain:The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin.,function:Specifically deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-10' of histone H3, and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.,PTM:Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. The phosphorylated form of the protein is also enzymatically active.,similarity:Belongs to the peptidase C19 family. USP16 subfamily.,similarity:Contains 1 UBP-type zinc finger.,subunit:Homotetramer.,tissue specificity:Present in all the tissues examined including fetal brain, lung, liver, kidney, and adult heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.