BD-PT4828-USP11 Rabbit Polyclonal Antibody-现货抗体产品库武汉枢密脑科学技术有限公司

USP11 Rabbit Polyclonal Antibody

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产品基本信息

产品货号

BD-PT4828

产品名称

USP11 Rabbit Polyclonal Antibody

别名

USP11; UHX1; Ubiquitin carboxyl-terminal hydrolase 11; Deubiquitinating enzyme 11; Ubiquitin thioesterase 11; Ubiquitin-specific-processing protease 11

类别

常规抗体

基因名称

USP11

蛋白名称

Ubiquitin carboxyl-terminal hydrolase 11

推荐应用

反应种属

Human,Mouse,Rat

浓度

1 mg/ml

存储缓冲液

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

Human Gene ID

8237

Human Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8237

Human Swissprot No.

P51784

Human Swissprot Link

http://www.uniprot.org/uniprotkb/P51784/entry

Mouse Gene ID

236733

Mouse Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=236733

Mouse Swissprot No.

Q99K46

Mouse Swissprot Link

http://www.uniprot.org/uniprot/Q99K46

免疫原

Synthesized peptide derived from the Internal region of human USP11.

特异性

USP11 Polyclonal Antibody detects endogenous levels of USP11 protein.

稀释度

IF 1:50-200 WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

预测分子量

105kD

运输及保存条件

-20°C/1 year

宿主

Polyclonal, Rabbit,IgG

背景介绍

Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11.23 [provided by RefSeq, Jul 2008],

组织表达

Brain,Fetal brain,Muscle,Retina,

细胞定位

Nucleus . Cytoplasm . Chromosome . Predominantly nuclear (PubMed:12084015, PubMed:15314155). Associates with chromatin (PubMed:20601937, PubMed:20233726). .

功能

catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 DUSP domain.,subunit:Interacts with RANBP9/RANBPM.,

期货

现货

纯化

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunofluorescence analysis of human-uterus tissue. 1,USP11 Polyclonal Antibody（red） was diluted at 1:200（4°,overnight）. 2, Cy3 labled Secondary antibody was diluted at 1:300（room temperature, 50min）.3, Picture B: DAPI（blue） 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B

Immunofluorescence analysis of human-lung tissue. 1,USP11 Polyclonal Antibody（red） was diluted at 1:200（4°,overnight）. 2, Cy3 labled Secondary antibody was diluted at 1:300（room temperature, 50min）.3, Picture B: DAPI（blue） 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B

Western Blot analysis of 293 cells using USP11 Polyclonal Antibody. Secondary antibody was diluted at 1:20000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit （SC-003,Inventbiotech,MN,USA）.