产品名称
UDP-GlcDH Rabbit Polyclonal Antibody
别名
UGDH; UDP-glucose 6-dehydrogenase; UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH
蛋白名称
UDP-glucose 6-dehydrogenase
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7358
Human Swissprot No.
O60701
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O60701/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22235
Mouse Swissprot No.
O70475
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O70475
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83472
Rat Swissprot Link
http://www.uniprot.org/uniprot/O70199
免疫原
The antiserum was produced against synthesized peptide derived from human UGDH. AA range:391-440
特异性
UDP-GlcDH Polyclonal Antibody detects endogenous levels of UDP-GlcDH protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010],
组织表达
Detected in heart, placenta, liver, pancreas, spleen, thymus, prostate, ovary, small intestine and colon (PubMed:9737970). Widely expressed (PubMed:9737970).
细胞定位
nucleus,nucleoplasm,cytosol,extracellular exosome,
信号通路
Pentose and glucuronate interconversions;Ascorbate and aldarate metabolism;Starch and sucrose metabolism;Amino sugar and nucleotide sugar metabolism;
功能
catalytic activity:UDP-glucose + 2 NAD(+) + H(2)O = UDP-glucuronate + 2 NADH.,function:Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.,pathway:Nucleotide-sugar biosynthesis; UDP-glucuronic acid biosynthesis; UDP-glucuronic acid from UDP-glucose: step 1/1.,similarity:Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.,subunit:Homohexamer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
