BD-PT4814

UCP3 Rabbit Polyclonal Antibody

UCP3; SLC25A9; Mitochondrial uncoupling protein 3; UCP 3; Solute carrier family 25 member 9

常规抗体

UCP3

Mitochondrial uncoupling protein 3

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

7352

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7352

P55916

http://www.uniprot.org/uniprotkb/P55916/entry

22229

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22229

P56501

http://www.uniprot.org/uniprot/P56501

25708

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25708

P56499

http://www.uniprot.org/uniprot/P56499

The antiserum was produced against synthesized peptide derived from human UCP3. AA range:259-308

UCP3 Polyclonal Antibody detects endogenous levels of UCP3 protein.

WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

33kD

-20°C/1 year

Polyclonal, Rabbit,IgG

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria.

Only in skeletal muscle and heart. Is more expressed in glycolytic than in oxidative skeletal muscles.

Mitochondrion inner membrane ; Multi-pass membrane protein .

disease:Defects in UCP3 may be involved in severe obesity [MIM:601665].,function:UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance.,similarity:Belongs to the mitochondrial carrier family.,similarity:Contains 3 Solcar repeats.,tissue specificity:Only in skeletal muscle and heart. Is more expressed in glycolytic than in oxidative skeletal muscles.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.