产品名称
UBR5 Rabbit Polyclonal Antibody
别名
UBR5; EDD; EDD1; HYD; KIAA0896; E3 ubiquitin-protein ligase UBR5; E3 ubiquitin-protein ligase; HECT domain-containing 1; Hyperplastic discs protein homolog; hHYD; Progestin-induced protein
蛋白名称
E3 ubiquitin-protein ligase UBR5
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51366
Human Swissprot No.
O95071
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O95071/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=70790
Mouse Swissprot No.
Q80TP3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q80TP3
免疫原
The antiserum was produced against synthesized peptide derived from human EDD. AA range:1-50
特异性
UBR5 Polyclonal Antibody detects endogenous levels of UBR5 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008],
组织表达
Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney.
信号通路
Ubiquitin mediated proteolysis;
功能
function:E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific amino-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). May be involved in maturation and/or transcriptional regulation of mRNA. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development.,miscellaneous:A cysteine residue is required for ubiquitin-thioester formation.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,similarity:Contains 1 PABC domain.,similarity:Contains 1 UBR-type zinc finger.,subunit:Binds TOPBP1.,tissue specificity:Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
