产品名称
UBE3C Rabbit Polyclonal Antibody
别名
UBE3C; KIAA0010; KIAA10; Ubiquitin-protein ligase E3C; HectH2
蛋白名称
Ubiquitin-protein ligase E3C
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=148581
Human Swissprot No.
Q15386
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q15386/entry
Mouse Swissprot No.
Q80U95
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q80U95
免疫原
Synthesized peptide derived from the Internal region of human UBE3C.
特异性
UBE3C Polyclonal Antibody detects endogenous levels of UBE3C protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
function:E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.,miscellaneous:A cysteine residue is required for ubiquitin-thioester formation.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,similarity:Contains 1 IQ domain.,subunit:Interacts with 26S proteasomes. Binds CAND2.,tissue specificity:Highly expressed in skeletal muscle. Detected at much lower levels in kidney and pancreas.,
组织表达
Highly expressed in skeletal muscle. Detected at much lower levels in kidney and pancreas.
细胞定位
proteasome complex,intracellular,nucleus,cytoplasm,
信号通路
Ubiquitin mediated proteolysis;
功能
function:E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.,miscellaneous:A cysteine residue is required for ubiquitin-thioester formation.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,similarity:Contains 1 IQ domain.,subunit:Interacts with 26S proteasomes. Binds CAND2.,tissue specificity:Highly expressed in skeletal muscle. Detected at much lower levels in kidney and pancreas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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